IUPAC Name :

2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester Benzenesulfonate

CAS Number :   111470-99-6

Structural Formula :

Molecular Weight :   05  g/mol

Molecular Formula:   C₂₆H₃₁ClN₂O₈S

Features of the API:

• Long-acting di-hydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
• Manufactured in an USFDA, WHO GMP, ISO 9001, OHSAS 18001 approved site.
• Available in standard pack size of 25 Kgs Net packed in HDPE Carbouys.

Mechanism of Action :

• Amlodipine is an angio-selective calcium channel blockerand inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells which inhibits the contraction of cardiac muscle and vascular smooth muscle cells. Amlodipine inhibits calcium ion influx across cell membranes, with a greater effect on vascular smooth muscle cells. This causes vasodilation and a reduction in peripheral vascular resistance, thus lowering blood pressure. Its effects on cardiac muscle also prevent excessive constriction in the coronary arteries.
• Amlodipine has additionally been found to act as an antagonistof the mineralocorticoid receptor, or as an anti-mineralocorticoid.