IUPAC Name :

N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxybenzamide; hydrochloride

CAS Number : 122892-31-3                                 

Mol. Formula :   C₂₀H₂₇ClN₂O₄

Structural Formula :

Molecular Weight :   89 g/mol

Features :

• A prokinetic benzamide derivative having a gastrokinetic
• Itopride is indicated for the treatment of functional dyspepsia and other gastrointestinal conditions. It is a combined D2 receptor antagonist and acetylcholinesterase inhibitor.
• Manufactured in an USFDA, WHO GMP, ISO 9001, OHSAS 18001 approved site.
• Available in standard pack size of 25 Kgs Net packed in HDPE Carbouys.

Mechanism of Action :

• Itopride increases acetylcholine concentrations by inhibiting dopamine D2 receptors and acetylcholinesterase. Higher acetylcholine increases GI peristalsis, increases the lower esophageal sphincter pressure, stimulates gastric motility, accelerates gastric emptying, and improves gastro-duodenal coordination.
• Itopride given as a single dose study found that it also raises levels of motilin, somatostatin and lowers levels of cholecystokinin, as well as adrenocorticotropic hormone. These effects may also contribute to itopride’s pharmacology.