IUPAC Name :

(1R)-1-[(2R)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-{[(2R)-2-[(2S)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-hydroxyethyl]amino}ethan-1-ol hydrochloride

CAS Number : 152520-56-4

Structural Formula :

Molecular Weight :   89  g/mol

Molecular Formula :   C₂₂H₂₆ClF₂NO₄

Features of the API :

• Highly cardio-selective vasodilatory beta1 receptor blocker used in treatment of hypertension, high blood pressure and heart failure. Mild vasodilating properties, possibly due to an interaction with the L-arginine/nitric oxide pathway.
• Manufactured in an USFDA, WHO GMP, ISO 9001, OHSAS 18001 approved site.
• Available in standard pack size of 25 Kgs Net packed in HDPE Carboys.

Mechanism of Action :

Nebivolol is a selective & beta;1 receptor antagonist. Activation of & beta;1 receptors by epinephrine increases the heart rate and the blood pressure, and the heart consumes more oxygen.

Nebivolol blocks these receptors which reverses the effects of epinephrine, lowering the heart rate and blood pressure.

In addition, beta blockers prevent the release of renin, which is a hormone produced by the kidneys which leads to constriction of blood vessels. At high enough concentrations, this drug may also bind beta 2 receptors.